New drug hope for children with primary bone cancer after pioneering Midlands research
Bone cancer in children may be cured by a new treatment developed after research into patients in the West Midlands.
The drug, which potentially works against all main types of primary bone cancer in children, has been described by the scientists who developed it as “the most important drug discovery in the field” for nearly half a century.
Tests showed the medicine – called CADD522 – is able to block a gene associated with helping cancer spread in mice implanted with human bone cancer.
The researchers, including scientists from Birmingham, said the findings, published in the Journal of Bone Oncology, showed the drug can increase survival rates by 50 per cent without the need for surgery or chemotherapy.
Lead researcher Dr Darrell Green said: “Primary bone cancer is a type of cancer that begins in the bones. It’s the third most common solid childhood cancer, after brain and kidney, with around 52,000 new cases every year worldwide.
“It can rapidly spread to other parts of the body, and this is the most problematic aspect of this type of cancer. Once the cancer has spread, it becomes very difficult to treat with curative intent.”
At present, the treatment for bone cancers is chemotherapy and limb amputation, which has a 42 per cent chance of survival. The researchers said their “breakthrough drug” increases survival rates by 50 per cent and does not come with harsh chemotherapy side-effects such as hair loss, tiredness and sickness.
For the study, the researchers analysed bone tumour samples from 19 patients at the Royal Orthopaedic Hospital in Birmingham.
They found that a gene, called RUNX2, is activated in primary bone cancer and is associated with driving the spread of the disease.
Tests showed CADD522 blocks the RUNX2 protein from helping cancer develop.
Dr Green said: “In preclinical trials, metastasis-free survival was increased by 50 per cent using the new CADD522 drug on its own, without chemotherapy or surgery.
“I’m optimistic that combined with other treatments such as surgery, this survival figure would be increased further.”
The research, funded by Sir William Coxen Trust and Big C, also included scientists from the University of Birmingham and Birmingham’s Royal Orthopaedic Hospital.
